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ifa-3 Intermediate filament protein ifa-3 [ Caenorhabditis elegans ]

Gene ID: 181699, updated on 2-Nov-2024

Summary

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Official Symbol
ifa-3
Official Full Name
Intermediate filament protein ifa-3
Primary source
WormBase:WBGene00002051
Locus tag
CELE_F52E10.5
See related
AllianceGenome:WB:WBGene00002051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in hypodermis and ventral cord neurons. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ifa-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (16267197..16270069, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase sgk-1 Neighboring gene ncRNA Neighboring gene Intermediate filament protein ifa-2 Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system. Karabinos A, et al. J Mol Biol, 2003 Oct 17. PMID 14529618
  2. Intermediate filaments are required for C. elegans epidermal elongation. Woo WM, et al. Dev Biol, 2004 Mar 1. PMID 14975728
  3. Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans. Dodemont H, et al. EMBO J, 1994 Jun 1. PMID 8013462, Free PMC Article
  4. Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs. Karabinos A. Gene, 2019 Apr 15. PMID 30641223
  5. Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans. Karabinos A, et al. Gene Expr Patterns, 2019 Dec. PMID 31207388

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear lamina IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Intermediate filament protein ifa-3
NP_510649.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16267197..16270069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078248.10 → NP_510649.3  Intermediate filament protein ifa-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510649.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20671, Q21065, Q94367
    Conserved Domains (4) summary
    pfam00038
    Location:71 → 419
    Filament; Intermediate filament protein
    pfam00932
    Location:462 → 570
    LTD; Lamin Tail Domain
    pfam06005
    Location:181 → 245
    DUF904; Protein of unknown function (DUF904)
    cl19219
    Location:140 → 209
    DUF342; Protein of unknown function (DUF342)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21065.1

Gene LinkOut

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