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sid-3 Tyrosine-protein kinase sid-3 [ Caenorhabditis elegans ]

Gene ID: 181756, updated on 4-Jan-2025

Summary

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Official Symbol
sid-3
Official Full Name
Tyrosine-protein kinase sid-3
Primary source
WormBase:WBGene00002207
Locus tag
CELE_B0302.1
See related
AllianceGenome:WB:WBGene00002207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytoplasm. Is expressed in several structures, including excretory canal; intestine; phasmid neurons; rectal gland cell; and somatic cell. Orthologous to several human genes including TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sid-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (17186380..17193292)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models. Nourse JB Jr, et al. Proc Natl Acad Sci U S A, 2023 Feb 14. PMID 36745808, Free PMC Article
  2. Natural Viruses of Caenorhabditis Nematodes. Félix MA, et al. Annu Rev Genet, 2019 Dec 3. PMID 31424970
  3. Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells. Jose AM, et al. Proc Natl Acad Sci U S A, 2012 Sep 4. PMID 22912399, Free PMC Article
  4. An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans. Tanguy M, et al. mBio, 2017 Sep 5. PMID 28874466, Free PMC Article
  5. An Evolutionarily Conserved Pathway Essential for Orsay Virus Infection of Caenorhabditis elegans. Jiang H, et al. mBio, 2017 Sep 5. PMID 28874467, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of CDC-42 or SID-3 suppressed trafficking process that requires actin assembly and disassembly.
    Title: Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.
  2. Systemic RNAi defective-3 (SID-3) is a conserved tyrosine kinase required for the efficient import of dsRNA.
    Title: Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase sid-3
NP_510783.2
  • Confirmed by transcript evidence
NP_510784.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    17186380..17193292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078383.7 → NP_510784.2  Tyrosine-protein kinase sid-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510784.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10925
    Conserved Domains (4) summary
    cd09539
    Location:9 → 70
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:107 → 363
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:371 → 421
    SH3; Src homology 3 domains
    cd05040
    Location:111 → 365
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

  2. NM_078382.7 → NP_510783.2  Tyrosine-protein kinase sid-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510783.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10925, Q7JP57, Q7JP58, Q7JP59, Q95ZZ7
    Conserved Domains (4) summary
    cd09539
    Location:9 → 70
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00221
    Location:107 → 363
    STYKc; Protein kinase; unclassified specificity
    smart00326
    Location:371 → 421
    SH3; Src homology 3 domains
    cd05040
    Location:111 → 365
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

RNA

  1. NR_136346.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10925.2

Gene LinkOut

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