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osm-11 Notch ligand osm-11 [ Caenorhabditis elegans ]

Gene ID: 181772, updated on 4-Jan-2025

Summary

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Official Symbol
osm-11
Official Full Name
Notch ligand osm-11
Primary source
WormBase:WBGene00003891
Locus tag
CELE_F11C7.5
See related
AllianceGenome:WB:WBGene00003891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables Notch binding activity. Involved in several processes, including positive regulation of Notch signaling pathway; response to osmotic stress; and vulval development. Located in apical part of cell and extracellular space. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; hermaphrodite gonad; and hypodermis. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See osm-11 in Genome Data Viewer
Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_003284.9 (17420211..17421468, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene UPF0506 domain-containing protein;Venom protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response. Dresen A, et al. Dev Biol, 2015 Apr 1. PMID 25637691
  2. Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Colbert HA, et al. Neuron, 1995 Apr. PMID 7718242
  3. Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network. Hoyos E, et al. Curr Biol, 2011 Apr 12. PMID 21458263, Free PMC Article
  4. An extracellular matrix damage sensor signals through membrane-associated kinase DRL-1 to mediate cytoprotective responses in Caenorhabditis elegans. Wimberly K, et al. Genetics, 2022 Mar 3. PMID 34849856, Free PMC Article
  5. LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction. Sorkaç A, et al. G3 (Bethesda), 2018 Jul 31. PMID 29950427, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response.
    Title: Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response.
  2. C. elegans OSM-11 and homologous proteins act as coactivators for Notch receptors, allowing precise regulation of Notch receptor signaling in developmental programs in both vertebrates and invertebrates.
    Title: OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Notch binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Notch ligand osm-11
NP_510823.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    17420211..17421468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078422.9 → NP_510823.1  Notch ligand osm-11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510823.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45346
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45346.1

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