tps-1 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tps-1
Official Full Name: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
Primary source: WormBase:WBGene00006602
Locus tag: CELE_ZK54.2
See related: AllianceGenome:WB:WBGene00006602
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Predicted to be involved in trehalose biosynthetic process and trehalose metabolism in response to stress. Is expressed in several structures, including enteric muscle; intestine; isthmus; nervous system; and reproductive system. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tps-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 21

Sequence:: Chromosome: X; NC_003284.9 (17467121..17474534, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK54.2 (e-PCR)
- UniSTS:310505

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables trehalose-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in trehalose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose metabolism in response to stress	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1

NP_001041302.1

Confirmed by transcript evidence

NP_001041303.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

17467121..17474534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047837.5 → NP_001041302.1 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041302.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23515, Q2L6W2, Q7YZT6

Conserved Domains (1) summary

cd03788
Location:325 → 801

GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
NM_001047838.4 → NP_001041303.1 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041303.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YZT6

Conserved Domains (1) summary

cd03788
Location:288 → 764

GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...