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Dusp8 dual specificity phosphatase 8 [ Mus musculus (house mouse) ]

Gene ID: 18218, updated on 27-Nov-2024

Summary

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Official Symbol
Dusp8provided by MGI
Official Full Name
dual specificity phosphatase 8provided by MGI
Primary source
MGI:MGI:106626
See related
Ensembl:ENSMUSG00000037887 AllianceGenome:MGI:106626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nttp1; 5530400B01Rik
Summary
Enables phosphatase activity. Involved in dephosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; placenta; retina; and yolk sac. Orthologous to human DUSP8 (dual specificity phosphatase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 20.5), CNS E18 (RPKM 19.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Dusp8 in Genome Data Viewer
Location:
7 F5; 7 87.59 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141633224..141649799, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142079487..142095907, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20498 Neighboring gene MOB kinase activator 2 Neighboring gene predicted gene, 25416 Neighboring gene predicted gene, 57785 Neighboring gene predicted gene 45417 Neighboring gene predicted gene, 32786 Neighboring gene keratin associated protein 5-26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dusp8 affects hippocampal size and behavior in mice and humans. Baumann P, et al. Sci Rep, 2019 Dec 20. PMID 31862894, Free PMC Article
  2. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Liu R, et al. Circ Res, 2016 Jul 8. PMID 27225478, Free PMC Article
  3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans. Baumann P, et al. Brain Behav, 2021 Jan. PMID 33131190, Free PMC Article
  4. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. Martell KJ, et al. J Neurochem, 1995 Oct. PMID 7561881
  5. A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region. Theodosiou AM, et al. Hum Mol Genet, 1996 May. PMID 8733137

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha.
    Title: DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α.
  2. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
    Title: Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration.
  3. Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
    Title: Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
  4. Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.
    Title: Mice lacking DUSP6/8 have enhanced ERK1/2 activity and resistance to diet-induced obesity.
  5. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
    Title: Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
  6. DUSP8 controls stress-induced ERK1/2 signaling in cardiac myocytes.
    Title: DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 8
Names
neuronal tyrosine threonine phosphatase 1
NP_032774.1
XP_006508572.1
XP_011240291.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008748.3 → NP_032774.1  dual specificity protein phosphatase 8

    See identical proteins and their annotated locations for NP_032774.1

    Status: VALIDATED

    Source sequence(s)
    AL603836, BC052705, BQ043453
    Consensus CDS
    CCDS22024.1
    UniProtKB/Swiss-Prot
    O09112
    UniProtKB/TrEMBL
    Q7TSZ9
    Related
    ENSMUSP00000049414.4, ENSMUST00000039926.10
    Conserved Domains (2) summary
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14645
    Location:150 → 300
    DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141633224..141649799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241989.4 → XP_011240291.1  dual specificity protein phosphatase 8 isoform X1

    See identical proteins and their annotated locations for XP_011240291.1

    UniProtKB/Swiss-Prot
    O09112
    UniProtKB/TrEMBL
    Q7TSZ9
    Conserved Domains (2) summary
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14645
    Location:150 → 300
    DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

  2. XM_006508509.5 → XP_006508572.1  dual specificity protein phosphatase 8 isoform X1

    See identical proteins and their annotated locations for XP_006508572.1

    UniProtKB/Swiss-Prot
    O09112
    UniProtKB/TrEMBL
    Q7TSZ9
    Conserved Domains (2) summary
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14645
    Location:150 → 300
    DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09112.1 GenPept UniProtKB/Swiss-Prot:O09112

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