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ubc-22 UBiquitin Conjugating enzyme [ Caenorhabditis elegans ]

Gene ID: 182322, updated on 4-Jan-2025

Summary

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Official Symbol
ubc-22
Official Full Name
UBiquitin Conjugating enzyme
Primary source
WormBase:WBGene00006717
Locus tag
CELE_C06E2.7
See related
AllianceGenome:WB:WBGene00006717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ubc-22 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (8867603..8869162, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene INSulin related Neighboring gene Ubiquitin-conjugating enzyme E2 21 Neighboring gene ncRNA Neighboring gene GYF domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans. Skibinski GA, et al. BMC Cell Biol, 2012 Apr 11. PMID 22494772, Free PMC Article
  2. Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans. Sampuda KM, et al. BMC Cell Biol, 2017 Apr 19. PMID 28424053, Free PMC Article
  3. Caenorhabditis elegans UBC-2 functions with the anaphase-promoting complex but also has other activities. Frazier T, et al. J Cell Sci, 2004 Oct 15. PMID 15466891
  4. The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Fatima A, et al. Commun Biol, 2020 May 25. PMID 32451438, Free PMC Article
  5. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UBiquitin Conjugating enzyme
NP_509501.2
  • Product from WormBase gene class ubc;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8867603..8869162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077100.6 → NP_509501.2  UBiquitin Conjugating enzyme [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509501.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17720
    Conserved Domains (2) summary
    cl00154
    Location:5 → 128
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl21463
    Location:139 → 174
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein
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