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Ocln occludin [ Mus musculus (house mouse) ]

Gene ID: 18260, updated on 27-Nov-2024

Summary

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Official Symbol
Oclnprovided by MGI
Official Full Name
occludinprovided by MGI
Primary source
MGI:MGI:106183
See related
Ensembl:ENSMUSG00000021638 AllianceGenome:MGI:106183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ocl
Summary
Predicted to enable protein domain specific binding activity. Involved in negative regulation of gene expression and tight junction organization. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and bicellular tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in large intestine adult (RPKM 9.2), colon adult (RPKM 5.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Ocln in Genome Data Viewer
Location:
13 D1; 13 53.23 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100633012..100689226, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100496504..100552718, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene general transcription factor II H, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E1467 Neighboring gene predicted gene, 57598 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2 Neighboring gene predicted gene, 24261

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR. Lu Y, et al. PLoS Biol, 2022 Jan. PMID 35041644, Free PMC Article
  2. Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance. Beeman NE, et al. BMC Cell Biol, 2009 Dec 9. PMID 20003227, Free PMC Article
  3. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Mir H, et al. Biochim Biophys Acta, 2016 Apr. PMID 26721332, Free PMC Article
  4. The oligomerization of the coiled coil-domain of occludin is redox sensitive. Walter JK, et al. Ann N Y Acad Sci, 2009 May. PMID 19538283
  5. Occludin protects secretory cells from ER stress by facilitating SNARE-dependent apical protein exocytosis. Zhou T, et al. Proc Natl Acad Sci U S A, 2020 Mar 3. PMID 32051248, Free PMC Article

See all (217) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd2O3 induced blood-testis barrier disruption.
    Title: LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd(2)O(3) induced blood-testis barrier disruption.
  2. Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma.
    Title: Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma.
  3. Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.
    Title: Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.
  4. The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.
    Title: The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.
  5. Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway.
    Title: Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway.
  6. Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice.
    Title: Epididymal epithelial degeneration and lipid metabolism impairment account for male infertility in occludin knockout mice.
  7. Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
    Title: Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
  8. The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.
    Title: The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.
  9. Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
    Title: Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
  10. The tight junction protein occludin regulates apoptosis by enhancing caspase-3 transcription in intestinal epithelial cells.
    Title: Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of D-glucose import IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interleukin-18 ISO
Inferred from Sequence Orthology
more info
  
involved_in tight junction organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
occludin
NP_001347465.1
NP_001347466.1
NP_001347467.1
NP_001347468.1
NP_032782.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360536.1 → NP_001347465.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000022140.6, ENSMUST00000022140.12
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  2. NM_001360537.1 → NP_001347466.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000124849.2, ENSMUST00000160859.8
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  3. NM_001360538.1 → NP_001347467.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

  4. NM_001360539.1 → NP_001347468.1  occludin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158536
    UniProtKB/TrEMBL
    Q3UKZ5
    Related
    ENSMUSP00000125642.2, ENSMUST00000159459.8
    Conserved Domains (1) summary
    pfam07303
    Location:225 → 324
    Occludin_ELL; Occludin homology domain

  5. NM_008756.2 → NP_032782.1  occludin isoform 1

    See identical proteins and their annotated locations for NP_032782.1

    Status: VALIDATED

    Source sequence(s)
    AK042576
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000065284.5, ENSMUST00000069756.11
    Conserved Domains (2) summary
    pfam01284
    Location:57 → 261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419 → 518
    Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100633012..100689226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61146.1 GenPept UniProtKB/Swiss-Prot:Q61146

Gene LinkOut

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