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prx-3 Peroxisomal assembly protein PEX3 [ Caenorhabditis elegans ]

Gene ID: 182644, updated on 4-Jan-2025

Summary

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Official Symbol
prx-3
Official Full Name
Peroxisomal assembly protein PEX3
Primary source
WormBase:WBGene00004193
Locus tag
CELE_C15H9.8
See related
AllianceGenome:WB:WBGene00004193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in protein import into peroxisome membrane. Predicted to be active in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 10B and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See prx-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (6110741..6112917, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane and coiled-coil domains protein 2 Neighboring gene UPAR/Ly6 domain-containing protein Neighboring gene Kynureninase Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans. Isermann K, et al. J Mol Biol, 2004 May 7. PMID 15099742
  2. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
  3. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
  4. Determining Toxic Potencies of Water-Soluble Contaminants in Wastewater Influents and Effluent Using Gene Expression Profiling in C. elegans as a Bioanalytical Tool. Karengera A, et al. Arch Environ Contam Toxicol, 2022 Oct. PMID 36190544, Free PMC Article
  5. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peroxisomal assembly protein PEX3
NP_001123111.1
  • Confirmed by transcript evidence
NP_001379676.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6110741..6112917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129639.3 → NP_001123111.1  Peroxisomal assembly protein PEX3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123111.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18028

  2. NM_001392784.1 → NP_001379676.1  Peroxisomal assembly protein PEX3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18027
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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