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C18H7.4 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 182803, updated on 4-Jan-2025

Summary

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Official Symbol
C18H7.4
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00015994
Locus tag
CELE_C18H7.4
See related
AllianceGenome:WB:WBGene00015994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See C18H7.4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (593329..595236)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RGS domain-containing protein Neighboring gene Aa_trans domain-containing protein Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain Neighboring gene CUB_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_499953.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    593329..595236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067552.6 → NP_499953.2  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499953.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GZG1
    Conserved Domains (3) summary
    cd10361
    Location:11 → 99
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd00192
    Location:126 → 373
    PTKc; Catalytic domain of Protein Tyrosine Kinases
    pfam07714
    Location:122 → 372
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
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