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swm-1 Serine protease inhibitor swm-1 [ Caenorhabditis elegans ]

Gene ID: 182893, updated on 4-Jan-2025

Summary

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Official Symbol
swm-1
Official Full Name
Serine protease inhibitor swm-1
Primary source
WormBase:WBGene00023417
Locus tag
CELE_C25E10.9
See related
AllianceGenome:WB:WBGene00023417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Is expressed in body wall musculature; coelomocyte; reproductive tract; and in male. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See swm-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (9054111..9054871, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TIL domain-containing protein Neighboring gene TIL domain-containing protein Neighboring gene TIL domain-containing protein Neighboring gene INSulin related Neighboring gene Prohormone-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sperm activation: time and tide wait for no sperm. Singson A. Curr Biol, 2006 Mar 7. PMID 16527731
  2. Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility. Chavez DR, et al. Development, 2018 Dec 18. PMID 30470702, Free PMC Article
  3. TRY-5 is a sperm-activating protease in Caenorhabditis elegans seminal fluid. Smith JR, et al. PLoS Genet, 2011 Nov. PMID 22125495, Free PMC Article
  4. Mutations in two independent pathways are sufficient to create hermaphroditic nematodes. Baldi C, et al. Science, 2009 Nov 13. PMID 19965511
  5. Male-specific roles of lincRNA in C. elegans fertility. Shabtai R, et al. Front Cell Dev Biol, 2023. PMID 37035238, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males.
    Title: Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine protease inhibitor swm-1
NP_505346.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9054111..9054871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072945.4 → NP_505346.1  Serine protease inhibitor swm-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18158
    Conserved Domains (1) summary
    pfam01826
    Location:20 → 73
    TIL; Trypsin Inhibitor like cysteine rich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18158.1

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