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nas-8 Zinc metalloproteinase nas-8 [ Caenorhabditis elegans ]

Gene ID: 183207, updated on 2-Nov-2024

Summary

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Official Symbol
nas-8
Official Full Name
Zinc metalloproteinase nas-8
Primary source
WormBase:WBGene00003527
Locus tag
CELE_C34D4.9
See related
AllianceGenome:WB:WBGene00003527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human ASTL (astacin like metalloendopeptidase); MEP1A (meprin A subunit alpha); and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nas-8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (7114899..7119926)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BAR domain-containing protein Neighboring gene Sperm-Specific family, class Q Neighboring gene CHASE2 domain-containing protein Neighboring gene Seven TM Receptor Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc metalloproteinase nas-8
NP_501114.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7114899..7119926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068713.7 → NP_501114.2  Zinc metalloproteinase nas-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501114.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18439, Q7Z0N4
    Conserved Domains (3) summary
    cd04280
    Location:123 → 304
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:119 → 308
    Astacin; Astacin (Peptidase family M12A)
    pfam01549
    Location:337 → 372
    ShK; ShK domain-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18439.3

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