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acc-2 Acetylcholine-gated chloride channel subunit acc-2 [ Caenorhabditis elegans ]

Gene ID: 183758, updated on 14-Nov-2024

Summary

Official Symbol
acc-2
Official Full Name
Acetylcholine-gated chloride channel subunit acc-2
Primary source
WormBase:WBGene00008280
Locus tag
CELE_C53D6.3
See related
AllianceGenome:WB:WBGene00008280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See acc-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (9016777..9019186)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Thioredoxin domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Acetylcholine-gated chloride channel subunit acc-2
NP_501567.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9016777..9019186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069166.3NP_501567.1  Acetylcholine-gated chloride channel subunit acc-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501567.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18812
    Conserved Domains (2) summary
    pfam02931
    Location:51258
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:267347
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region