Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf11bprovided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)provided by MGI
Primary source: MGI:MGI:109587
See related: Ensembl:ENSMUSG00000063727 AllianceGenome:MGI:109587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Opg; TR1; OCIF
Summary: Enables heparan sulfate binding activity. Involved in negative regulation of osteoclast differentiation. Acts upstream of or within extracellular matrix organization; negative regulation of odontogenesis of dentin-containing tooth; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; hemolymphoid system gland; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 3.7), liver E18 (RPKM 2.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 21.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (54114014..54141700, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (54250619..54278484, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osteoprotegerin Is Essential for the Development of Endothelial Dysfunction Induced by Angiotensin II in Mice.
Title: Osteoprotegerin Is Essential for the Development of Endothelial Dysfunction Induced by Angiotensin II in Mice.
Osteoprotegerin mediates adipogenesis in obesity.
Title: Osteoprotegerin mediates adipogenesis in obesity.
Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage.
Title: Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage.
Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study.
Title: Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study.
Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Title: Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Genetic deletion of osteoprotegerin attenuates asthma development through suppression of inflammatory response in mice.
Title: Genetic deletion of osteoprotegerin attenuates asthma development through suppression of inflammatory response in mice.
Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.
Title: Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling.
LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1.
Title: LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1.
Incretins Enhance PGF2alpha-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts.
Title: Incretins Enhance PGF2α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts.
Osteoprotegerin Expression in Liver is Induced by IL13 through TGFbeta.
Title: Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Tnfrsf11b (e-PCR), detects polymorphism
- UniSTS:532245

AB013898 (e-PCR)
- UniSTS:160452

Tnfrsf11b (e-PCR), detects polymorphism
- UniSTS:144084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparan sulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to magnesium ion	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 11B

Names: osteoclastogenesis inhibitory factor; osteoprotegerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411506.1 → NP_001398435.1 tumor necrosis factor receptor superfamily member 11B isoform 2

Status: VALIDATED

Source sequence(s)

AC121114
NM_008764.4 → NP_032790.3 tumor necrosis factor receptor superfamily member 11B isoform 1 precursor

See identical proteins and their annotated locations for NP_032790.3

Status: VALIDATED

Source sequence(s)

AC121114

Consensus CDS

CCDS27468.1

UniProtKB/Swiss-Prot

O08712, O70202

UniProtKB/TrEMBL

Q3UK97, Q6PI12

Related

ENSMUSP00000078705.4, ENSMUST00000079772.4

Conserved Domains (3) summary

cd00185
Location:122 → 185

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

cd10581
Location:7 → 151

TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)

pfam00531
Location:293 → 365

Death; Death domain