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rpb-12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 [ Caenorhabditis elegans ]

Gene ID: 184886, updated on 2-Nov-2024

Summary

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Official Symbol
rpb-12
Official Full Name
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Primary source
WormBase:WBGene00009078
Locus tag
CELE_F23B2.13
See related
AllianceGenome:WB:WBGene00009078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I; transcription by RNA polymerase II; and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpb-12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9146334..9146869, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport protein 122 homolog Neighboring gene ncRNA Neighboring gene SQPNFLRF-amide Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Mattout A, et al. Nat Cell Biol, 2020 May. PMID 32251399, Free PMC Article
  2. Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness. Geens E, et al. Life Sci Alliance, 2023 Jun. PMID 37059473, Free PMC Article
  3. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC4
NP_001380171.1
  • Confirmed by transcript evidence
NP_501593.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9146334..9146869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392364.1 → NP_001380171.1  DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M5N4

  2. NM_069192.2 → NP_501593.1  DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501593.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3I0
    Conserved Domains (1) summary
    smart00659
    Location:19 → 62
    RPOLCX; RNA polymerase subunit CX
Nucleotide Protein
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