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asah-2 putative acid ceramidase [ Caenorhabditis elegans ]

Gene ID: 185021, updated on 2-Nov-2024

Summary

Official Symbol
asah-2
Official Full Name
putative acid ceramidase
Primary source
WormBase:WBGene00009192
Locus tag
CELE_F27E5.1
See related
AllianceGenome:WB:WBGene00009192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in fatty acid metabolic process and sphingolipid metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See asah-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (10139590..10141406)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Growth arrest-specific protein 1 homolog Neighboring gene Uncharacterized protein Neighboring gene Paired box protein 3 homolog Neighboring gene Neuropeptide-Like Protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N-acylsphingosine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-acylsphingosine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid amide hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative acid ceramidase
NP_496187.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10139590..10141406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063786.4NP_496187.1  putative acid ceramidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496187.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09551
    Conserved Domains (2) summary
    cd01903
    Location:138385
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:52143
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase