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spe-45 Ig-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185063, updated on 4-Jan-2025

Summary

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Official Symbol
spe-45
Official Full Name
Ig-like domain-containing protein
Primary source
WormBase:WBGene00009217
Locus tag
CELE_F28D1.8
See related
AllianceGenome:WB:WBGene00009217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See spe-45 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (12387689..12390095, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS12 Neighboring gene ncRNA Neighboring gene putative dolichol-phosphate mannosyltransferase subunit 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans spermatozoa lacking spe-45 are incapable of fusing with the oocyte plasma membrane. Takayama J, et al. MicroPubl Biol, 2021 Feb 21. PMID 33644705, Free PMC Article
  2. Marriage shrines and worms impacting our understanding of mammalian fertilization. Krauchunas AR, et al. Worm, 2016. PMID 27695649, Free PMC Article
  3. Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization. Singaravelu G, et al. Curr Biol, 2015 Dec 21. PMID 26671668, Free PMC Article
  4. Gamete interactions require transmembranous immunoglobulin-like proteins with conserved roles during evolution. Nishimura H, et al. Worm, 2016. PMID 27695654, Free PMC Article
  5. The Immunoglobulin-like Gene spe-45 Acts during Fertilization in Caenorhabditis elegans like the Mouse Izumo1 Gene. Nishimura H, et al. Curr Biol, 2015 Dec 21. PMID 26671669, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. encodes a single-pass transmembrane protein with a single immunoglobulin domain; required for male fertility
    Title: Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ig-like domain-containing protein
NP_001309449.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12387689..12390095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322777.2 → NP_001309449.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19879
    Conserved Domains (1) summary
    cd00096
    Location:176 → 230
    Ig; Immunoglobulin domain
Nucleotide Protein
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