U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

set-11 SET domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185242, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
set-11
Official Full Name
SET domain-containing protein
Primary source
WormBase:WBGene00018023
Locus tag
CELE_F34D6.4
See related
AllianceGenome:WB:WBGene00018023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3 methyltransferase activity; protein-lysine N-methyltransferase activity; and zinc ion binding activity. Involved in innate immune response. Predicted to be located in chromosome and nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in Kleefstra syndrome; Kleefstra syndrome 1; and idiopathic pulmonary fibrosis. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1) and EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See set-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (2690472..2692576, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nematode Specific Peptide family, group F Neighboring gene Nematode Specific Peptide family, group F Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class I Neighboring gene Serpentine Receptor, class H

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development. Simonet T, et al. Dev Biol, 2007 Dec 1. PMID 17967446
  2. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, et al. Nature, 2010 Jul 15. PMID 20555324, Free PMC Article
  3. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
  4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
  5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SET domain-containing protein
NP_001364763.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2690472..2692576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377732.1 → NP_001364763.1  SET domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17186
    Conserved Domains (2) summary
    smart00468
    Location:21 → 117
    PreSET; N-terminal to some SET domains
    cl40432
    Location:75 → 270
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools