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Cdk18 cyclin dependent kinase 18 [ Mus musculus (house mouse) ]

Gene ID: 18557, updated on 27-Nov-2024

Summary

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Official Symbol
Cdk18provided by MGI
Official Full Name
cyclin dependent kinase 18provided by MGI
Primary source
MGI:MGI:97518
See related
Ensembl:ENSMUSG00000026437 AllianceGenome:MGI:97518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctk18; Pctk3
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and lung. Orthologous to human CDK18 (cyclin dependent kinase 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 63.9), small intestine adult (RPKM 44.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Cdk18 in Genome Data Viewer
Location:
1 E4; 1 57.24 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132041285..132067433, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132113547..132139698, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998691-133998892 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133998935-133999044 Neighboring gene predicted gene, 37120 Neighboring gene predicted gene, 30153 Neighboring gene predicted gene, 30242

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A. Matsuda S, et al. J Biol Chem, 2014 Jun 27. PMID 24831015, Free PMC Article
  2. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. Okuda T, et al. Genomics, 1994 May 1. PMID 8088790
  3. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Okuda T, et al. Oncogene, 1992 Nov. PMID 1437147
  4. Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation. Rhee K, et al. Dev Dyn, 1995 Dec. PMID 8601034
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The activity of PCTK3 is increased via interaction with cyclin A2 and phosphorylation by PKA.
    Title: PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 18
Names
PCTAIRE-motif protein kinase 3
cell division protein kinase 18
serine/threonine-protein kinase PCTAIRE-3
NP_032821.1
XP_011246242.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008795.2 → NP_032821.1  cyclin-dependent kinase 18

    See identical proteins and their annotated locations for NP_032821.1

    Status: VALIDATED

    Source sequence(s)
    AK004998, BQ177094, CJ070016
    Consensus CDS
    CCDS15281.1
    UniProtKB/Swiss-Prot
    Q04899
    UniProtKB/TrEMBL
    Q0VDL6
    Related
    ENSMUSP00000027697.6, ENSMUST00000027697.12
    Conserved Domains (2) summary
    PLN00009
    Location:118 → 407
    PLN00009; cyclin-dependent kinase A; Provisional
    cl21453
    Location:115 → 402
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132041285..132067433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247940.4 → XP_011246242.1  cyclin-dependent kinase 18 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:38 → 325
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_387152.5 RNA Sequence

  2. XR_001783189.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04899.1 GenPept UniProtKB/Swiss-Prot:Q04899

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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