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F42G2.5 Major sperm protein [ Caenorhabditis elegans ]

Gene ID: 185673, updated on 4-Jan-2025

Summary

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Official Symbol
F42G2.5
Official Full Name
Major sperm protein
Primary source
WormBase:WBGene00018354
Locus tag
CELE_F42G2.5
See related
AllianceGenome:WB:WBGene00018354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein-membrane adaptor activity. Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum-plasma membrane tethering. Predicted to be located in cytoskeleton. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F42G2.5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (2415997..2417989, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FTH domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Phytanoyl-CoA dioxygenase;phytanoyl-CoA dioxygenase Neighboring gene F-box C protein Neighboring gene ncRNA Neighboring gene DUF38 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of cross-linked peptides from complex samples. Yang B, et al. Nat Methods, 2012 Sep. PMID 22772728
  2. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
  3. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum-plasma membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Major sperm protein
NP_494271.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2415997..2417989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061870.2 → NP_494271.1  Major sperm protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17099
    Conserved Domains (3) summary
    smart00184
    Location:134 → 178
    RING; Ring finger
    pfam00635
    Location:7 → 110
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15905
    Location:174 → 329
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
Nucleotide Protein
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