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snt-2 Synaptotagmin 2 [ Caenorhabditis elegans ]

Gene ID: 185680, updated on 4-Jan-2025

Summary

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Official Symbol
snt-2
Official Full Name
Synaptotagmin 2
Primary source
WormBase:WBGene00004922
Locus tag
CELE_F42G9.7
See related
AllianceGenome:WB:WBGene00004922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Located in dense core granule. Is expressed in head neurons; intestine; and tail neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See snt-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (786070..793733, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 4-trimethylaminobutyraldehyde dehydrogenase Neighboring gene sn-1-specific diacylglycerol lipase Neighboring gene Protein phosphatase ppm-1.G Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS14 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior. Wang H, et al. Curr Biol, 2013 May 6. PMID 23583549, Free PMC Article
  2. Neuropeptide signaling: from the gut. Zhao B, et al. Curr Biol, 2013 Jun 3. PMID 23743414
  3. Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair. Choi U, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972428, Free PMC Article
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dense core granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Synaptotagmin 2
NP_497261.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    786070..793733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064860.6 → NP_497261.2  Synaptotagmin 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497261.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    K8FE10
    Conserved Domains (2) summary
    cd08402
    Location:217 → 357
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    cl14603
    Location:85 → 206
    C2; C2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
K8FE10.1

Gene LinkOut

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