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mkk-4 MAP kinase kinase mkk-4 [ Caenorhabditis elegans ]

Gene ID: 185682, updated on 14-Nov-2024

Summary

Official Symbol
mkk-4
Official Full Name
MAP kinase kinase mkk-4
Primary source
WormBase:WBGene00003368
Locus tag
CELE_F42G10.2
See related
AllianceGenome:WB:WBGene00003368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of axon extension involved in regeneration; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm. Is expressed in head; hypodermis; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See mkk-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (10027856..10030130)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Peptidase_M13 domain-containing protein;Peptidase_M13_N domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidase_M13 domain-containing protein Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase Neighboring gene Fibronectin type-III domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension involved in regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MAP kinase kinase mkk-4
NP_509682.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10027856..10030130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077281.7NP_509682.1  MAP kinase kinase mkk-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509682.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01707, Q20347
    Conserved Domains (2) summary
    smart00220
    Location:72329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:59347
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4