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otpl-5 Otopetrin-2 [ Caenorhabditis elegans ]

Gene ID: 185806, updated on 4-Jan-2025

Summary

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Official Symbol
otpl-5
Official Full Name
Otopetrin-2
Primary source
WormBase:WBGene00018478
Locus tag
CELE_F45F2.5
See related
AllianceGenome:WB:WBGene00018478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See otpl-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (8529519..8532465)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Otopetrin-2 Neighboring gene ncRNA Neighboring gene OToPetrin-Like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histone H2B 2 Neighboring gene Histone H2A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Hughes I, et al. BMC Evol Biol, 2008 Feb 6. PMID 18254951, Free PMC Article
  2. An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, et al. Science, 2018 Mar 2. PMID 29371428, Free PMC Article
  3. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, et al. Hum Mol Genet, 2003 Apr 1. PMID 12651873
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton channel activity IEA
Inferred from Electronic Annotation
more info
  
enables proton channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Otopetrin-2
NP_505196.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8529519..8532465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072795.4 → NP_505196.2  Otopetrin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505196.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4SFC1
    Conserved Domains (1) summary
    pfam03189
    Location:145 → 536
    Otopetrin; Otopetrin
Nucleotide Protein
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