U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

scl-1 SCP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186053, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
scl-1
Official Full Name
SCP domain-containing protein
Primary source
WormBase:WBGene00004742
Locus tag
CELE_F49E11.9
See related
AllianceGenome:WB:WBGene00004742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in determination of adult lifespan; response to UV; and response to heat. Predicted to be active in extracellular space. Orthologous to several human genes including PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See scl-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (13056326..13057351)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein phosphatase Neighboring gene pseudo Neighboring gene SCP domain-containing protein Neighboring gene SCP domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Direct and indirect transcriptional targets of DAF-16. Larsen PL. Sci Aging Knowledge Environ, 2003 Apr 30. PMID 12844535
  2. Toxicogenomic effects of nano- and bulk-TiO2 particles in the soil nematode Caenorhabditis elegans. Rocheleau S, et al. Nanotoxicology, 2015 May. PMID 25211548
  3. Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Ookuma S, et al. Curr Biol, 2003 Mar 4. PMID 12620193
  4. CAP protein superfamily members in Toxocara canis. Stroehlein AJ, et al. Parasit Vectors, 2016 Jun 24. PMID 27342979, Free PMC Article
  5. Aging: new targets, new functions. Patterson GI. Curr Biol, 2003 Apr 1. PMID 12676107

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Required for the extension of the life span of daf-2 and age-1 mutants, down-regulation reduces life span and stress resistance.
    Title: Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SCP domain-containing protein
NP_502502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13056326..13057351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070101.3 → NP_502502.1  SCP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20608
    Conserved Domains (1) summary
    smart00198
    Location:19 → 174
    SCP; SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous