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dgn-2 Peptidase S72 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186365, updated on 4-Jan-2025

Summary

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Official Symbol
dgn-2
Official Full Name
Peptidase S72 domain-containing protein
Primary source
WormBase:WBGene00018943
Locus tag
CELE_F56C3.6
See related
AllianceGenome:WB:WBGene00018943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable laminin binding activity. Predicted to be involved in axon guidance; morphogenesis of an epithelium; and nerve development. Predicted to be located in membrane. Predicted to be part of dystroglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dgn-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (1365474..1367516, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF4129 domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MHC class II antigen K

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans dystroglycan DGN-1 functions in epithelia and neurons, but not muscle, and independently of dystrophin. Johnson RP, et al. Development, 2006 May. PMID 16611689
  2. A new role for laminins as modulators of protein toxicity in Caenorhabditis elegans. Jensen LT, et al. Aging Cell, 2012 Feb. PMID 22051349, Free PMC Article
  3. Basement membranes. Kramer JM. WormBook, 2005 Sep 1. PMID 18050423, Free PMC Article
  4. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Ziel JW, et al. Nat Cell Biol, 2009 Feb. PMID 19098902, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of dystroglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dystrophin-associated glycoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase S72 domain-containing protein
NP_508253.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1365474..1367516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075852.1 → NP_508253.1  Peptidase S72 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508253.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61756
    Conserved Domains (1) summary
    pfam05454
    Location:197 → 356
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
Nucleotide Protein
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