xpg-1 XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: xpg-1
Official Full Name: XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog
Primary source: WormBase:WBGene00019004
Locus tag: CELE_F57B10.6
See related: AllianceGenome:WB:WBGene00019004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity; endonuclease activity; and metal ion binding activity. Predicted to be involved in DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See xpg-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (6558694..6562346)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F57B10.6 (e-PCR)
- UniSTS:311897

F57B10.7 (e-PCR)
- UniSTS:311898

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog

NP_491891.2

Product from WormBase gene class xpg;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6558694..6562346

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059490.4 → NP_491891.2 XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491891.2

Status: REVIEWED

UniProtKB/TrEMBL

O44737

Conserved Domains (2) summary

cd09900
Location:554 → 586

H3TH_XPG-like; H3TH domains of Flap endonuclease-1 (FEN1)-like structure specific 5' nucleases: FEN1 (archaeal), GEN1, YEN1, and XPG

cl14812
Location:1 → 111

PIN_SF; PIN (PilT N terminus) domain: Superfamily