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F59A3.8 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 186579, updated on 14-Nov-2024

Summary

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Official Symbol
F59A3.8
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00019081
Locus tag
CELE_F59A3.8
See related
AllianceGenome:WB:WBGene00019081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F59A3.8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (5522392..5525340, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Carboxypeptidase D Neighboring gene PAP-associated domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_491620.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5522392..5525340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059219.5 → NP_491620.2  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491620.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91360
    Conserved Domains (3) summary
    smart00219
    Location:312 → 568
    TyrKc; Tyrosine kinase, catalytic domain
    cd10361
    Location:165 → 286
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd00192
    Location:314 → 570
    PTKc; Catalytic domain of Protein Tyrosine Kinases
Nucleotide Protein
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