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ant-1.3 ADP/ATP translocase [ Caenorhabditis elegans ]

Gene ID: 186855, updated on 2-Nov-2024

Summary

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Official Symbol
ant-1.3
Official Full Name
ADP/ATP translocase
Primary source
WormBase:WBGene00010485
Locus tag
CELE_K01H12.2
See related
AllianceGenome:WB:WBGene00010485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable adenine nucleotide transmembrane transporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrial inner membrane. Is expressed in VA11 and intestine. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A5 (solute carrier family 25 member 5) and SLC25A6 (solute carrier family 25 member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ant-1.3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9708168..9709305, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DDB1- and CUL4-associated factor homolog 1 Neighboring gene ncRNA Neighboring gene DPH-type MB domain-containing protein;Diphthamide biosynthesis protein 3 Neighboring gene Nuclear receptor domain-containing protein Neighboring gene Breast cancer type 2 susceptibility protein homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans. Farina F, et al. Dev Dyn, 2008 Jun. PMID 18498090
  2. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Shen Q, et al. Mol Cell Biol, 2009 Jul. PMID 19414600, Free PMC Article
  3. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Zhou B, et al. Cell, 2019 Apr 4. PMID 30929899, Free PMC Article
  4. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Statzer C, et al. Nat Commun, 2022 Feb 18. PMID 35181679, Free PMC Article
  5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables adenine nucleotide transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP/ATP translocase
NP_501727.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9708168..9709305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069326.5 → NP_501727.1  ADP/ATP translocase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501727.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFW8
    Conserved Domains (2) summary
    PTZ00169
    Location:25 → 313
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:21 → 120
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
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