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cbp-2 histone acetyltransferase [ Caenorhabditis elegans ]

Gene ID: 186960, updated on 2-Nov-2024

Summary

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Official Symbol
cbp-2
Official Full Name
histone acetyltransferase
Primary source
WormBase:WBGene00010545
Locus tag
CELE_K03H1.10
See related
AllianceGenome:WB:WBGene00010545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone acetyltransferase activity; metal ion binding activity; and transcription coregulator activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cbp-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (9923174..9924800)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene USP domain-containing protein Neighboring gene pseudo Neighboring gene Transthyretin-like protein 3 Neighboring gene Transthyretin-like protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Lundblad JR, et al. Nature, 1995 Mar 2. PMID 7870179
  2. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
  3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  4. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone acetyltransferase
NP_499201.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9923174..9924800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066800.5 → NP_499201.1  histone acetyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBG3
    Conserved Domains (2) summary
    pfam02135
    Location:23 → 99
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:166 → 242
    KIX; KIX domain
Nucleotide Protein
Heading Accession and Version

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