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dnj-15 J domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187149, updated on 2-Nov-2024

Summary

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Official Symbol
dnj-15
Official Full Name
J domain-containing protein
Primary source
WormBase:WBGene00001033
Locus tag
CELE_K08D10.2
See related
AllianceGenome:WB:WBGene00001033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnj-15 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (4176388..4178364)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene tRNA-intron lyase;tRNA_int_endo domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
  2. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in [2Fe-2S] cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
J domain-containing protein
NP_001294564.1
  • Confirmed by transcript evidence
NP_500506.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4176388..4178364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068105.3 → NP_500506.2  J domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500506.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21324
    Conserved Domains (1) summary
    PRK05014
    Location:51 → 204
    hscB; co-chaperone HscB; Provisional

  2. NM_001307635.3 → NP_001294564.1  J domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294564.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PF47
    Conserved Domains (1) summary
    PRK00294
    Location:6 → 115
    hscB; co-chaperone HscB; Provisional
Nucleotide Protein
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