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cyp-14A1 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 187183, updated on 9-Dec-2024

Summary

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Official Symbol
cyp-14A1
Official Full Name
CYtochrome P450 family
Primary source
WormBase:WBGene00010705
Locus tag
CELE_K09A11.2
See related
AllianceGenome:WB:WBGene00010705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyp-14A1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (13265041..13267355, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BED-type domain-containing protein Neighboring gene tRNA-Tyr Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan. Lim SYM, et al. J Appl Toxicol, 2024 Nov. PMID 38472099
  2. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Held JP, et al. Elife, 2022 Apr 22. PMID 35451962, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CYtochrome P450 family
NP_510203.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13265041..13267355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077802.5 → NP_510203.1  CYtochrome P450 family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27506
    Conserved Domains (1) summary
    pfam00067
    Location:27 → 483
    p450; Cytochrome P450
Nucleotide Protein
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