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cyp-14A3 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 187185, updated on 9-Dec-2024

Summary

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Official Symbol
cyp-14A3
Official Full Name
CYtochrome P450 family
Primary source
WormBase:WBGene00010707
Locus tag
CELE_K09A11.4
See related
AllianceGenome:WB:WBGene00010707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyp-14A3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (13271837..13274202, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan. Lim SYM, et al. J Appl Toxicol, 2024 Nov. PMID 38472099
  2. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. Chakrapani BP, et al. J Biosci, 2008 Jun. PMID 18535361
  3. Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Kulas J, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18282462
  4. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
  5. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CYtochrome P450 family
NP_510205.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13271837..13274202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077804.4 → NP_510205.1  CYtochrome P450 family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510205.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27507
    Conserved Domains (1) summary
    pfam00067
    Location:27 → 483
    p450; Cytochrome P450
Nucleotide Protein
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