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set-12 SET domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187229, updated on 4-Jan-2025

Summary

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Official Symbol
set-12
Official Full Name
SET domain-containing protein
Primary source
WormBase:WBGene00019584
Locus tag
CELE_K09F5.5
See related
AllianceGenome:WB:WBGene00019584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3K36 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in germ line and hypodermis. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See set-12 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (7733334..7736271, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein Neighboring gene Vitellogenin-1 Neighboring gene RGS domain-containing protein Neighboring gene Zinc finger transcription factor ref-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model. Guijarro-Hernández A, et al. Cells, 2023 Jan 2. PMID 36611979, Free PMC Article
  2. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, et al. Nature, 2010 Jul 15. PMID 20555324, Free PMC Article
  3. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
  4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SET domain-containing protein
NP_509306.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7733334..7736271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076905.6 → NP_509306.2  SET domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509306.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21404
    Conserved Domains (2) summary
    smart00570
    Location:53 → 94
    AWS; associated with SET domains
    smart00317
    Location:97 → 221
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
Nucleotide Protein
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