U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pira2 paired-Ig-like receptor A2 [ Mus musculus (house mouse) ]

Gene ID: 18725, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pira2provided by MGI
Official Full Name
paired-Ig-like receptor A2provided by MGI
Primary source
MGI:MGI:1195970
See related
Ensembl:ENSMUSG00000089942 AllianceGenome:MGI:1195970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6M23
Summary
Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRA6 (leukocyte immunoglobulin like receptor A6); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 17.0), mammary gland adult (RPKM 8.6) and 13 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pira2 in Genome Data Viewer
Location:
7 A1; 7 2.21 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3839807..3848102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3836808..3845104, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene paired-Ig-like receptor A2, pseudogene 1 Neighboring gene paired-Ig-like receptor A13 Neighboring gene STARR-positive B cell enhancer mm9_chr7:3796869-3797170 Neighboring gene predicted pseudogene 10693 Neighboring gene paired-Ig-like receptor A12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Kubagawa H, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144225, Free PMC Article
  2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgM binding ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
paired-Ig-like receptor A2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379689.1 → NP_001366618.1  paired-Ig-like receptor A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161409
    UniProtKB/TrEMBL
    A2NTJ9
    Conserved Domains (3) summary
    cd00096
    Location:123 → 127
    Ig; Ig strand A [structural motif]
    cd16843
    Location:224 → 313
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:122 → 218
    Ig; Immunoglobulin domain

  2. NM_011089.2 → NP_035219.2  paired-Ig-like receptor A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035219.2

    Status: VALIDATED

    Source sequence(s)
    AC161409, AK140776
    Consensus CDS
    CCDS39731.1
    UniProtKB/TrEMBL
    A2NTJ9, F8VQ94
    Related
    ENSMUSP00000104255.4, ENSMUST00000108615.10
    Conserved Domains (2) summary
    smart00410
    Location:529 → 617
    IG_like; Immunoglobulin like
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3839807..3848102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539625.3 → XP_006539688.1  paired-Ig-like receptor A2 isoform X6

    UniProtKB/TrEMBL
    A2NTJ9
    Conserved Domains (1) summary
    cl11960
    Location:130 → 220
    Ig; Immunoglobulin domain

  2. XM_036152785.1 → XP_036008678.1  paired-Ig-like receptor A2 isoform X5

    UniProtKB/TrEMBL
    D3Z3W9, O70434
    Related
    ENSMUSP00000113857.2, ENSMUST00000119469.2
    Conserved Domains (3) summary
    cd00096
    Location:124 → 128
    Ig; Ig strand A [structural motif]
    cd16843
    Location:225 → 314
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:123 → 219
    Ig; Immunoglobulin domain

  3. XM_036152782.1 → XP_036008675.1  paired-Ig-like receptor A2 isoform X2

    UniProtKB/TrEMBL
    A2NTJ9
    Conserved Domains (3) summary
    cd00096
    Location:129 → 133
    Ig; Ig strand A [structural motif]
    cd16843
    Location:230 → 319
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:128 → 224
    Ig; Immunoglobulin domain

  4. XM_036152783.1 → XP_036008676.1  paired-Ig-like receptor A2 isoform X3

    UniProtKB/TrEMBL
    A2NTJ9
    Conserved Domains (3) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cd16843
    Location:231 → 320
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:129 → 225
    Ig; Immunoglobulin domain

  5. XM_036152784.1 → XP_036008677.1  paired-Ig-like receptor A2 isoform X4

    UniProtKB/TrEMBL
    O70434
    Conserved Domains (3) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cd16843
    Location:231 → 320
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:129 → 225
    Ig; Immunoglobulin domain

  6. XM_036152781.1 → XP_036008674.1  paired-Ig-like receptor A2 isoform X1

    UniProtKB/TrEMBL
    A2NTJ9
    Conserved Domains (3) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cd16843
    Location:231 → 320
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:129 → 225
    Ig; Immunoglobulin domain

RNA

  1. XR_004934041.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous