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Lilra6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 [ Mus musculus (house mouse) ]

Gene ID: 18726, updated on 27-Nov-2024

Summary

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Official Symbol
Lilra6provided by MGI
Official Full Name
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6provided by MGI
Primary source
MGI:MGI:1195969
See related
Ensembl:ENSMUSG00000030427 AllianceGenome:MGI:1195969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
7M1; Pira3
Summary
Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Is expressed in embryo. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRA6 (leukocyte immunoglobulin like receptor A6); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 11.9), mammary gland adult (RPKM 6.3) and 14 other tissues See more
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Genomic context

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See Lilra6 in Genome Data Viewer
Location:
7 A1; 7 2.25 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3911276..3918569, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3908277..3915571, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10693 Neighboring gene paired-Ig-like receptor A12 Neighboring gene RIKEN cDNA 1700095K22 gene Neighboring gene STARR-seq mESC enhancer starr_17915 Neighboring gene predicted gene 7363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. Kelsey L, et al. PLoS Genet, 2013. PMID 23874215, Free PMC Article
  2. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Kubagawa H, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144225, Free PMC Article
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgM binding ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
paired-Ig-like receptor A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011090.2 → NP_035220.2  paired-Ig-like receptor A3 precursor

    See identical proteins and their annotated locations for NP_035220.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AK152898, BB665966, BC127613
    Consensus CDS
    CCDS20728.1
    UniProtKB/TrEMBL
    A0A0B4J1F3, A2NTK0
    Related
    ENSMUSP00000042636.9, ENSMUST00000038176.15
    Conserved Domains (2) summary
    smart00410
    Location:529 → 617
    IG_like; Immunoglobulin like
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

RNA

  1. NR_028115.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and unlikely to make a functional protein.
    Source sequence(s)
    AK152898, BC119598
    Related
    ENSMUST00000206077.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3911276..3918569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539630.5 → XP_006539693.1  paired-Ig-like receptor A3 isoform X2

    See identical proteins and their annotated locations for XP_006539693.1

    UniProtKB/TrEMBL
    D3Z674
    Conserved Domains (1) summary
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

  2. XM_006539632.5 → XP_006539695.1  paired-Ig-like receptor A3 isoform X3

    UniProtKB/TrEMBL
    A2NTK0
    Conserved Domains (1) summary
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

  3. XM_036152786.1 → XP_036008679.1  paired-Ig-like receptor A3 isoform X4

    UniProtKB/TrEMBL
    A2NTK2
    Conserved Domains (2) summary
    cd00096
    Location:124 → 128
    Ig; Ig strand A [structural motif]
    cl11960
    Location:123 → 219
    Ig; Immunoglobulin domain

  4. XM_006539629.4 → XP_006539692.1  paired-Ig-like receptor A3 isoform X1

    UniProtKB/TrEMBL
    E9Q6M9
    Conserved Domains (1) summary
    cl11960
    Location:123 → 219
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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