M04C9.3 Pyroglutamyl-peptidase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: M04C9.3
Official Full Name: Pyroglutamyl-peptidase 1
Primary source: WormBase:WBGene00010858
Locus tag: CELE_M04C9.3
See related: AllianceGenome:WB:WBGene00010858
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Orthologous to several human genes including PGPEP1L (pyroglutamyl-peptidase I like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See M04C9.3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (9352847..9354612, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M04C9.3 (e-PCR)
- UniSTS:314697

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pyroglutamyl-peptidase 1

NP_001129785.1

Confirmed by transcript evidence

NP_492491.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9352847..9354612 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060090.7 → NP_492491.3 Pyroglutamyl-peptidase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

P90933

Conserved Domains (1) summary

cd00501
Location:30 → 228

Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
NM_001136313.4 → NP_001129785.1 Pyroglutamyl-peptidase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129785.1

Status: REVIEWED

UniProtKB/TrEMBL

B3WFY7

Conserved Domains (1) summary

cd00501
Location:3 → 201

Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...