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bbs-5 BBSome complex member bbs-5 [ Caenorhabditis elegans ]

Gene ID: 187516, updated on 4-Jan-2025

Summary

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Official Symbol
bbs-5
Official Full Name
BBSome complex member bbs-5
Primary source
WormBase:WBGene00010974
Locus tag
CELE_R01H10.6
See related
AllianceGenome:WB:WBGene00010974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in cilium assembly and intracellular transport. Located in ciliary base; cytoskeleton; and non-motile cilium. Is expressed in head; nervous system; and tail. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 5. Orthologous to human BBS5 (Bardet-Biedl syndrome 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See bbs-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10258831..10261782, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Coronin-like protein cor-1 Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner Neighboring gene PH domain-containing protein Neighboring gene Connector enhancer of kinase suppressor of ras Neighboring gene GDP-fucose protein O-fucosyltransferase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors. Xu Q, et al. Sci Rep, 2015 Jul 7. PMID 26150102, Free PMC Article
  2. Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes. Bentley-Ford MR, et al. Genetics, 2022 Jan 4. PMID 34850872, Free PMC Article
  3. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding. Akella JS, et al. Elife, 2020 Feb 26. PMID 32101165, Free PMC Article
  4. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Li JB, et al. Cell, 2004 May 14. PMID 15137946
  5. Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Piasecki BP, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615967, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of BBSome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BBSome IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BBSome complex member bbs-5
NP_499272.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10258831..10261782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066871.2 → NP_499272.1  BBSome complex member bbs-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499272.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21626
    Conserved Domains (2) summary
    smart00683
    Location:30 → 84
    DM16; Repeats in sea squirt COS41.4, worm R01H10.6, fly CG1126 etc
    pfam07289
    Location:9 → 357
    DUF1448; Protein of unknown function (DUF1448)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21626.1

Gene LinkOut

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