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cnk-1 Connector enhancer of kinase suppressor of ras [ Caenorhabditis elegans ]

Gene ID: 187518, updated on 2-Nov-2024

Summary

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Official Symbol
cnk-1
Official Full Name
Connector enhancer of kinase suppressor of ras
Primary source
WormBase:WBGene00000564
Locus tag
CELE_R01H10.8
See related
AllianceGenome:WB:WBGene00000564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to several human genes including CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cnk-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (10271257..10278579)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner Neighboring gene BBSome complex member bbs-5 Neighboring gene PH domain-containing protein Neighboring gene GDP-fucose protein O-fucosyltransferase 2 Neighboring gene Bestrophin homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Clapéron A, et al. Oncogene, 2007 May 14. PMID 17496912
  2. Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Rocheleau CE, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16085714, Free PMC Article
  3. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Rocheleau CE, et al. Genetics, 2008 Mar. PMID 18245826, Free PMC Article
  4. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
  5. RTK/Ras/MAPK signaling. Sundaram MV. WormBook, 2006 Feb 11. PMID 18050474, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Review highlights the implication of CNK and KSR in a novel mechanism regulating RAS-mediated RAF activation.
    Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
  2. CNK promotes Raf phosphorylation/activation through membrane localization
    Title: Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Connector enhancer of kinase suppressor of ras
NP_001391083.1
  • Partially confirmed by transcript evidence
NP_499274.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10271257..10278579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066873.7 → NP_499274.3  Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499274.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEW9
    Conserved Domains (6) summary
    smart00454
    Location:53 → 119
    SAM; Sterile alpha motif
    cd00992
    Location:267 → 337
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00169
    Location:636 → 736
    PH; PH domain
    pfam10534
    Location:129 → 219
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl15755
    Location:53 → 118
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17171
    Location:636 → 731
    PH-like; Pleckstrin homology-like domain

  2. NM_001404166.1 → NP_001391083.1  Connector enhancer of kinase suppressor of ras [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D9I9L4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEW9.1

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