U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gskl-1 Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5 [ Caenorhabditis elegans ]

Gene ID: 187536, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
gskl-1
Official Full Name
Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5
Primary source
WormBase:WBGene00010991
Locus tag
CELE_R03D7.5
See related
AllianceGenome:WB:WBGene00010991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of microtubule cytoskeleton organization. Predicted to be active in axon; cytosol; and nucleus. Is expressed in germ line; gonad; sperm; spermatocyte; and in male. [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See gskl-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (10947559..10949263)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Phage protein Neighboring gene Transcription elongation factor B polypeptide 3 Neighboring gene GST C-terminal domain-containing protein;putative glutathione S-transferase 5 Neighboring gene Nanos-type domain-containing protein Neighboring gene Serine/threonine specific protein phosphatases domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sperm-specific glycogen synthase kinase 3 is required for sperm motility and the post-fertilization signal for female meiosis II in Caenorhabditis elegans. Banerjee RP, et al. Development, 2022 May 15. PMID 35635101
  2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5
NP_001300575.1
  • Confirmed by transcript evidence
NP_496356.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10947559..10949263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063955.4 → NP_496356.2  Putative serine/threonine-protein kinase R03D7.5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496356.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09595
    Conserved Domains (2) summary
    smart00220
    Location:23 → 304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:15 → 307
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001313646.1 → NP_001300575.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AR32
    Conserved Domains (1) summary
    cl21453
    Location:8 → 33
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09595.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.