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gst-5 GST C-terminal domain-containing protein;putative glutathione S-transferase 5 [ Caenorhabditis elegans ]

Gene ID: 187537, updated on 2-Nov-2024

Summary

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Official Symbol
gst-5
Official Full Name
GST C-terminal domain-containing protein;putative glutathione S-transferase 5
Primary source
WormBase:WBGene00001753
Locus tag
CELE_R03D7.6
See related
AllianceGenome:WB:WBGene00001753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutathione transferase activity. Involved in innate immune response. Is expressed in intestine; nerve ring; and pharynx. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gst-5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (10950352..10951603)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phage protein Neighboring gene Transcription elongation factor B polypeptide 3 Neighboring gene Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5 Neighboring gene Nanos-type domain-containing protein Neighboring gene Serine/threonine specific protein phosphatases domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional analysis of a glutathione S-transferase from Ascaris suum. Liebau E, et al. Biochem J, 1997 Jun 1. PMID 9182731, Free PMC Article
  2. Heme transport and detoxification in nematodes: subproteomics evidence of differential role of glutathione transferases. Perally S, et al. J Proteome Res, 2008 Oct. PMID 18720983
  3. A proteomics approach to quantify protein levels following RNA interference: case study with glutathione transferase superfamily from the model metazoan Caenorhabditis elegans. Lacourse EJ, et al. J Proteome Res, 2008 Aug. PMID 18582093
  4. Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. Wang C, et al. Environ Pollut, 2019 Mar. PMID 31159140
  5. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
GST C-terminal domain-containing protein;putative glutathione S-transferase 5
NP_001254267.1
  • Confirmed by transcript evidence
NP_001254269.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10950352..10951603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267338.3 → NP_001254267.1  putative glutathione S-transferase 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254267.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09596
    Conserved Domains (2) summary
    cd03192
    Location:85 → 189
    GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
    cd03039
    Location:4 → 75
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

  2. NM_001267340.3 → NP_001254269.1  GST C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254269.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MTX8
    Conserved Domains (1) summary
    pfam14497
    Location:3 → 91
    GST_C_3; Glutathione S-transferase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09596.1

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