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Pkia protein kinase inhibitor, alpha [ Mus musculus (house mouse) ]

Gene ID: 18767, updated on 27-Nov-2024

Summary

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Official Symbol
Pkiaprovided by MGI
Official Full Name
protein kinase inhibitor, alphaprovided by MGI
Primary source
MGI:MGI:104747
See related
Ensembl:ENSMUSG00000027499 AllianceGenome:MGI:104747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKIalpha
Summary
Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 76.3), whole brain E14.5 (RPKM 43.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Pkia in Genome Data Viewer
Location:
3 A1; 3 1.96 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (7431695..7510426)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (7366604..7445366)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41991 Neighboring gene STARR-seq mESC enhancer starr_06828 Neighboring gene STARR-seq mESC enhancer starr_06829 Neighboring gene STARR-seq mESC enhancer starr_06830 Neighboring gene STARR-seq mESC enhancer starr_06831 Neighboring gene STARR-seq mESC enhancer starr_06832 Neighboring gene STARR-seq mESC enhancer starr_06833 Neighboring gene STARR-seq mESC enhancer starr_06834 Neighboring gene predicted gene 8823 Neighboring gene STARR-seq mESC enhancer starr_06835 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 pseudogene Neighboring gene predicted gene, 23592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. Hoy JJ, et al. FASEB J, 2020 Oct. PMID 32830375, Free PMC Article
  2. Deficient gene expression in protein kinase inhibitor alpha Null mutant mice. Gangolli EA, et al. Mol Cell Biol, 2000 May. PMID 10779334, Free PMC Article
  3. Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase. Olsen SR, et al. J Biol Chem, 1991 Jun 15. PMID 1710219
  4. Reproductive function in protein kinase inhibitor-deficient mice. Belyamani M, et al. Mol Cell Biol, 2001 Jun. PMID 11359903, Free PMC Article
  5. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Kim J, et al. Structure, 2016 Mar 1. PMID 26833386, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein kinase A inhibitor proteins (PKIs) divert GPCR-Galphas-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth.
    Title: Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of cAMP/PKA signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cAMP/PKA signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor alpha
Names
PKI-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410515.1 → NP_001397444.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0

  2. NM_001410516.1 → NP_001397445.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0

  3. NM_001410520.1 → NP_001397449.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0

  4. NM_001410524.1 → NP_001397453.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0

  5. NM_001410525.1 → NP_001397454.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0

  6. NM_001410526.1 → NP_001397455.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0

  7. NM_001410527.1 → NP_001397456.1  cAMP-dependent protein kinase inhibitor alpha

    Status: VALIDATED

    Source sequence(s)
    AC123876
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0
    Related
    ENSMUSP00000141466.2, ENSMUST00000193330.2

  8. NM_008862.4 → NP_032888.1  cAMP-dependent protein kinase inhibitor alpha

    See identical proteins and their annotated locations for NP_032888.1

    Status: VALIDATED

    Source sequence(s)
    AC123876, AC132094
    Consensus CDS
    CCDS38383.1
    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0
    Related
    ENSMUSP00000028999.7, ENSMUST00000028999.12
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    7431695..7510426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162942.1 → XP_036018835.1  cAMP-dependent protein kinase inhibitor alpha isoform X2

    UniProtKB/Swiss-Prot
    P27776, P63248, Q3UTL0
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63248.2 GenPept UniProtKB/Swiss-Prot:P63248

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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