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ocr-3 Ion transport domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 188364, updated on 2-Nov-2024

Summary

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Official Symbol
ocr-3
Official Full Name
Ion transport domain-containing protein
Primary source
WormBase:WBGene00003840
Locus tag
CELE_T10B10.7
See related
AllianceGenome:WB:WBGene00003840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in rectal gland cell. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5) and TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ocr-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Sequence:
Chromosome: X; NC_003284.9 (15168724..15173636)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nucleotide-diphospho-sugar transferase Neighboring gene Secreted protein Neighboring gene Peptidase M16 N-terminal domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene PH domain-containing protein;RUN domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function and regulation of TRP family channels in C. elegans. Xiao R, et al. Pflugers Arch, 2009 Sep. PMID 19421772, Free PMC Article
  2. Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. Tobin DM, et al. Neuron, 2002 Jul 18. PMID 12160748
  3. Invertebrate TRP proteins as functional models for mammalian channels. Vriens J, et al. Pflugers Arch, 2004 Dec. PMID 15480752
  4. Studying TRP Channels in Caenorhabditis elegans. Zhu MX, et al. , 2011. PMID 22593955
  5. Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Glauser DA, et al. Genetics, 2011 May. PMID 21368276, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ion transport domain-containing protein
NP_510520.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15168724..15173636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078119.8 → NP_510520.4  Ion transport domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510520.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22374
    Conserved Domains (2) summary
    TIGR00870
    Location:136 → 801
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:182 → 242
    ANK; ANK repeat [structural motif]
Nucleotide Protein
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