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aat-6 Amino acid transporter protein 6 [ Caenorhabditis elegans ]

Gene ID: 188421, updated on 9-Dec-2024

Summary

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Official Symbol
aat-6
Official Full Name
Amino acid transporter protein 6
Primary source
WormBase:WBGene00000007
Locus tag
CELE_T11F9.4
See related
AllianceGenome:WB:WBGene00000007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables PDZ domain binding activity. Predicted to be involved in amino acid transmembrane transport. Located in apical plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aat-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (11466842..11470663, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zrt (ZRT), Irt- (IRT-) like Protein Transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-20 Neighboring gene Zinc metalloproteinase-like protein nas-21

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane. Hagiwara K, et al. PLoS One, 2012. PMID 22916205, Free PMC Article
  2. The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply. Spanier B, et al. Front Mol Biosci, 2018. PMID 30560135, Free PMC Article
  3. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. Veljkovic E, et al. J Biol Chem, 2004 Feb 27. PMID 14668347
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Amino acid transporter protein 6
NP_001123014.1
  • Confirmed by transcript evidence
NP_505905.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11466842..11470663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073504.5 → NP_505905.2  Amino acid transporter protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505905.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6M4, Q22397
    Conserved Domains (1) summary
    TIGR00911
    Location:18 → 482
    2A0308; L-type amino acid transporter

  2. NM_001129542.4 → NP_001123014.1  Amino acid transporter protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123014.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2D6M4
    Conserved Domains (1) summary
    TIGR00911
    Location:8 → 472
    2A0308; L-type amino acid transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22397.2

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