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cdf-2 Zinc transporter 2 [ Caenorhabditis elegans ]

Gene ID: 188574, updated on 2-Nov-2024

Summary

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Official Symbol
cdf-2
Official Full Name
Zinc transporter 2
Primary source
WormBase:WBGene00011821
Locus tag
CELE_T18D3.3
See related
AllianceGenome:WB:WBGene00011821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monoatomic cation transmembrane transporter activity. Involved in cellular response to zinc ion and zinc ion transmembrane transport. Located in gut granule membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdf-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (12464640..12466917, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The effect of metal mixture composition on toxicity to C. elegans at individual and population levels. Moyson S, et al. PLoS One, 2019. PMID 31237916, Free PMC Article
  2. Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis. Mendoza AD, et al. Proc Natl Acad Sci U S A, 2024 Feb 13. PMID 38330011, Free PMC Article
  3. Zinc oxide/graphene oxide nanocomposites specifically remediated Cd-contaminated soil via reduction of bioavailability and ecotoxicity of Cd. Li Y, et al. Sci Total Environ, 2024 Aug 25. PMID 38825205
  4. ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. Roh HC, et al. PLoS Genet, 2013 May. PMID 23717214, Free PMC Article
  5. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identify cdf-2 as a new gene that has a critical role in zinc storage
    Title: The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to zinc ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in gut granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Zinc transporter 2
NP_001300381.1
  • Confirmed by transcript evidence
NP_510091.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12464640..12466917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077690.4 → NP_510091.2  Zinc transporter 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510091.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22541
    Conserved Domains (3) summary
    TIGR01297
    Location:63 → 343
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:64 → 266
    Cation_efflux; Cation efflux family
    pfam16916
    Location:276 → 343
    ZT_dimer; Dimerization domain of Zinc Transporter

  2. NM_001313452.1 → NP_001300381.1  Zinc transporter 2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVP5
    Conserved Domains (1) summary
    TIGR01297
    Location:1 → 43
    CDF; cation diffusion facilitator family transporter
Nucleotide Protein
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