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phy-3 Fe2OG dioxygenase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 188624, updated on 4-Jan-2025

Summary

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Official Symbol
phy-3
Official Full Name
Fe2OG dioxygenase domain-containing protein
Primary source
WormBase:WBGene00004026
Locus tag
CELE_T20B3.7
See related
AllianceGenome:WB:WBGene00004026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in spermatheca. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See phy-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (16833165..16839141)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H Neighboring gene Troponin I 3 Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Myllyharju J. Matrix Biol, 2003 Mar. PMID 12714038
  2. Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties. Riihimaa P, et al. J Biol Chem, 2002 May 17. PMID 11891226
  3. Characterization of a novel Caenorhabditis elegans prolyl 4-hydroxylase with a unique substrate specificity and restricted expression in the pharynx and excretory duct. Keskiaho K, et al. J Biol Chem, 2008 Apr 18. PMID 18276589
  4. The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits. Myllyharju J, et al. J Biol Chem, 2002 Aug 9. PMID 12036960
  5. Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo. Topf U, et al. Mol Biol Cell, 2011 Sep. PMID 21795395, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fe2OG dioxygenase domain-containing protein
NP_507251.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16833165..16839141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074850.3 → NP_507251.2  Fe2OG dioxygenase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507251.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUP0
    Conserved Domains (1) summary
    smart00702
    Location:102 → 277
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
Nucleotide Protein
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