U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lgc-53 Neur_chan_memb domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 188702, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
lgc-53
Official Full Name
Neur_chan_memb domain-containing protein
Primary source
WormBase:WBGene00020657
Locus tag
CELE_T21F2.1
See related
AllianceGenome:WB:WBGene00020657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in neurons. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See lgc-53 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (16711681..16720670)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histone deacetylase 4

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Antagonistic effect of dopamine structural analogues on human GABAρ1 receptor. Alaniz-Palacios A, et al. Sci Rep, 2017 Dec 12. PMID 29234054, Free PMC Article
  2. Fast phasic release properties of dopamine studied with a channel biosensor. Kress GJ, et al. J Neurosci, 2014 Aug 27. PMID 25164674, Free PMC Article
  3. Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Ringstad N, et al. Science, 2009 Jul 3. PMID 19574391, Free PMC Article
  4. Amphetamine potentiates the effects of β-phenylethylamine through activation of an amine-gated chloride channel. Safratowich BD, et al. J Neurosci, 2014 Mar 26. PMID 24672014, Free PMC Article
  5. Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. Barros AG, et al. PLoS One, 2014. PMID 24465759, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Neur_chan_memb domain-containing protein
NP_001379650.1
  • Confirmed by transcript evidence
NP_741945.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16711681..16720670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171812.7 → NP_741945.3  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741945.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYN9
    Conserved Domains (3) summary
    TIGR00860
    Location:87 → 489
    LIC; Cation transporter family protein
    pfam02931
    Location:88 → 294
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:302 → 486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_001392910.1 → NP_001379650.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PJ95
    Conserved Domains (1) summary
    TIGR00860
    Location:1 → 270
    LIC; Cation transporter family protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous