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asd-2 K Homology domain-containing protein;RNA-binding protein asd-2 [ Caenorhabditis elegans ]

Gene ID: 188703, updated on 2-Nov-2024

Summary

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Official Symbol
asd-2
Official Full Name
K Homology domain-containing protein;RNA-binding protein asd-2
Primary source
WormBase:WBGene00006423
Locus tag
CELE_T21G5.5
See related
AllianceGenome:WB:WBGene00006423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in P granule and nucleus. Part of ribonucleoprotein complex. Is expressed in body wall musculature; hypodermis; and pharyngeal muscle cell. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See asd-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (6877059..6892143, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine receptor class beta-15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Ohno G, et al. Genes Dev, 2008 Feb 1. PMID 18230701, Free PMC Article
  2. C. elegans star proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development. Lee MH, et al. Adv Exp Med Biol, 2010. PMID 21189689
  3. KH domain containing RNA-binding proteins coordinate with microRNAs to regulate Caenorhabditis elegans development. Haskell D, et al. G3 (Bethesda), 2021 Feb 9. PMID 33585875, Free PMC Article
  4. Switch-like regulation of tissue-specific alternative pre-mRNA processing patterns revealed by customized fluorescence reporters. Kuroyanagi H. Worm, 2013 Jul 1. PMID 24778931, Free PMC Article
  5. High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLD-1, STAR-2 and Quaking. Carmel AB, et al. BMC Mol Biol, 2010 Jun 23. PMID 20573244, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
    Title: Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
  2. We isolated several switching-defective mutants and identified the alternative splicing defective-2 (asd-2) gene, encoding a novel member of the evolutionarily conserved STAR (signal transduction activators of RNA) family of RNA-binding proteins.
    Title: STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA intronic binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
K Homology domain-containing protein;RNA-binding protein asd-2
NP_001021625.1
  • Partially confirmed by transcript evidence
NP_001021626.1
  • Confirmed by transcript evidence
NP_001021627.1
  • Confirmed by transcript evidence
NP_001250340.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6877059..6892143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001263411.2 → NP_001250340.1  K Homology domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001250340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4YW53, G4S8D2
    Conserved Domains (2) summary
    cd02395
    Location:161 → 283
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16544
    Location:95 → 145
    STAR_dimer; Homodimerization region of STAR domain protein

  2. NM_001026455.6 → NP_001021626.1  RNA-binding protein asd-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021626.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF1
    Conserved Domains (2) summary
    cd02395
    Location:89 → 211
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16544
    Location:23 → 74
    STAR_dimer; Homodimerization region of STAR domain protein

  3. NM_001026456.4 → NP_001021627.1  RNA-binding protein asd-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF1, G5EFG9, O02065
    Conserved Domains (2) summary
    cd02395
    Location:131 → 253
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16544
    Location:65 → 116
    STAR_dimer; Homodimerisation region of STAR domain protein

  4. NM_001026454.5 → NP_001021625.1  RNA-binding protein asd-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021625.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF1
    Conserved Domains (2) summary
    cd02395
    Location:89 → 211
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16544
    Location:23 → 74
    STAR_dimer; Homodimerization region of STAR domain protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFF1.1

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