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glt-4 Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4 [ Caenorhabditis elegans ]

Gene ID: 188744, updated on 2-Nov-2024

Summary

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Official Symbol
glt-4
Official Full Name
Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4
Primary source
WormBase:WBGene00001622
Locus tag
CELE_T22E5.2
See related
AllianceGenome:WB:WBGene00001622
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head neurons and metacorpus. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria; episodic ataxia type 6; schizophrenia 18; and spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to several human genes including SLC1A1 (solute carrier family 1 member 1) and SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glt-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (6403422..6408411)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Troponin T Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity. Mano I, et al. J Neurochem, 2009 Mar. PMID 19054279
  2. Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse. Mano I, et al. J Biol Chem, 2007 Nov 23. PMID 17681948
  3. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Li P, et al. Neuron, 2016 May 4. PMID 27151641, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4
NP_001379386.1
  • Confirmed by transcript evidence
NP_509075.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6403422..6408411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076674.8 → NP_509075.3  Putative sodium-dependent excitatory amino acid transporter glt-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509075.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22682
    Conserved Domains (1) summary
    pfam00375
    Location:10 → 454
    SDF; Sodium:dicarboxylate symporter family

  2. NM_001392788.1 → NP_001379386.1  Amino acid transporter [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7R9SUN6
    Conserved Domains (1) summary
    pfam00375
    Location:10 → 454
    SDF; Sodium:dicarboxylate symporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22682.3

Gene LinkOut

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