lbp-8 Fatty acid-binding protein homolog 8 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: lbp-8
Official Full Name: Fatty acid-binding protein homolog 8
Primary source: WormBase:WBGene00002260
Locus tag: CELE_T22G5.6
See related: AllianceGenome:WB:WBGene00002260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables long-chain fatty acid transmembrane transporter activity and oleic acid binding activity. Involved in long-chain fatty acid transport. Located in lysosome and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G. Orthologous to several human genes including FABP12 (fatty acid binding protein 12); FABP7 (fatty acid binding protein 7); and FABP9 (fatty acid binding protein 9). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	TAS Traceable Author Statement more info	PubMed
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oleic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport	TAS Traceable Author Statement more info	PubMed
involved_in long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_506444.2

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The following sections contain reference sequences that belong to a specific genome build. Explain