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cdka-1 Cyclin-dependent kinase 5 activator 1 [ Caenorhabditis elegans ]

Gene ID: 188812, updated on 4-Jan-2025

Summary

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Official Symbol
cdka-1
Official Full Name
Cyclin-dependent kinase 5 activator 1
Primary source
WormBase:WBGene00011955
Locus tag
CELE_T23F11.3
See related
AllianceGenome:WB:WBGene00011955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Involved in several processes, including GABAergic synaptic transmission; regulation of dense core granule transport; and synaptic vesicle transport. Predicted to be located in axon cytoplasm; dendrite; and synapse. Predicted to be part of protein kinase 5 complex. Predicted to be active in cytoplasm and growth cone. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1) and CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cdka-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (4658794..4662702)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitin ligase activity inhibits Cdk5 to control axon termination. Desbois M, et al. PLoS Genet, 2022 Apr. PMID 35421092, Free PMC Article
  2. Effect of dys-1 mutation on gene expression profile in space-flown Caenorhabditis elegans. Xu D, et al. Muscle Nerve, 2018 Jan 18. PMID 29346705
  3. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Juo P, et al. Mol Biol Cell, 2007 Oct. PMID 17671168, Free PMC Article
  4. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. Goodwin PR, et al. J Neurosci, 2012 Jun 13. PMID 22699897, Free PMC Article
  5. Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. Park EC, et al. EMBO J, 2012 Mar 21. PMID 22252129, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dense core granule transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase 5 complex IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cyclin-dependent kinase 5 activator 1
NP_001076649.1
  • Confirmed by transcript evidence
NP_001076650.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4658794..4662702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083181.6 → NP_001076650.1  Cyclin-dependent kinase 5 activator 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076650.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22695
    Conserved Domains (1) summary
    pfam03261
    Location:18 → 362
    CDK5_activator; Cyclin-dependent kinase 5 activator protein

  2. NM_001083180.4 → NP_001076649.1  Cyclin-dependent kinase 5 activator 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0G843, Q22695
    Conserved Domains (1) summary
    pfam03261
    Location:18 → 352
    CDK5_activator; Cyclin-dependent kinase 5 activator protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22695.2

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