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nlp-22 Neuropeptide-Like Protein [ Caenorhabditis elegans ]

Gene ID: 188855, updated on 4-Jan-2025

Summary

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Official Symbol
nlp-22
Official Full Name
Neuropeptide-Like Protein
Primary source
WormBase:WBGene00003760
Locus tag
CELE_T24D8.3
See related
AllianceGenome:WB:WBGene00003760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in embryo development and positive regulation of error-prone translesion synthesis. Is expressed in head and ventral nerve cord. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nlp-22 in Genome Data Viewer
Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_003284.9 (2341359..2342089, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New alleles of nlp-2 , nlp-22 , and nlp-23 demonstrate that they are dispensable for stress-induced sleep in C. elegans. Aviles S, et al. MicroPubl Biol, 2024. PMID 38371321, Free PMC Article
  2. The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans. Nelson MD, et al. Nat Commun, 2013. PMID 24301180, Free PMC Article
  3. RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans. Van der Auwera P, et al. Sci Rep, 2020 Jun 18. PMID 32555288, Free PMC Article
  4. Neuropeptide-like protein diversity in phylum Nematoda. McVeigh P, et al. Int J Parasitol, 2008 Nov. PMID 18602104
  5. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The neuropeptide NLP-22 is a regulator of sleep-like quiescence observed during lethargus.
    Title: The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of error-prone translesion synthesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of error-prone translesion synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Neuropeptide-Like Protein
NP_508424.1
  • Product from WormBase gene class nlp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2341359..2342089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076023.4 → NP_508424.1  Neuropeptide-Like Protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22737
Nucleotide Protein
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